5 Amino 1MQ
A selective NNMT inhibitor that promotes fat cell metabolism by blocking a key enzyme involved in energy storage, researched for obesity treatment and metabolic reprogramming of white adipose tissue. All presented information is based on scientific publications which can be found at the end of product description below.
Product Specifications
Descriere
Toate informațiile prezentate se bazează pe publicații științifice, care pot fi consultate la sfârșitul descrierii produsului, mai jos.
5-Amino-1-methylquinolinium (5-Amino-1MQ) inhibits nicotinamide N-methyltransferase (NNMT), an enzyme regulating cellular metabolism and energy homeostasis, promoting a shift from energy storage toward expenditure.
Research Highlights
1. NNMT Inhibition — Blocks methylation of nicotinamide, preserving methyl groups for epigenetic modifications.
2. Adipose Metabolism — Increases NAD+ and SAM in adipocytes, enhancing mitochondrial activity and reducing lipid accumulation without affecting food intake.
3. Obesity Research — Reduced body weight and fat mass in diet-induced obesity models while improving glucose tolerance.
4. Metabolic Reprogramming — Modulates NAD+ salvage pathway and methylation balance, potentially reversing pro-obesity gene expression.
5. Cancer — NNMT overexpression in several cancer types; inhibition shows anti-proliferative effects.
References available upon request.
The product is intended for scientific research and development purposes only. Chemical substances shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals. Intended only for in-vitro research, such as Receptor-ligand binding studies, Enzyme activity assays, Cell proliferation assays, Cell signaling assays, Epitope mapping, etc.
Doar pentru uz de cercetare: Produsul este destinat exclusiv scopurilor de cercetare științifică și dezvoltare. Substanțele chimice nu trebuie utilizate ca medicament, substanță activă, ajutor medical, produs cosmetic, substanță pentru producerea unui produs cosmetic și nici pentru consum uman ca aliment sau supliment alimentar și nici utilizate în alt mod similar pe oameni sau animale. Destinat exclusiv pentru cercetare in-vitro, precum studii de legare receptor-ligand, teste de activitate enzimatică, teste de proliferare celulară, teste de semnalizare celulară, mapare a epitopilor etc.
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Întrebări frecvente
- 5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), not a peptide. Molecular weight ≈ 257-321 g/mol depending on counter-ion. Included in our catalog as a research tool for metabolism and adipocyte biology studies.
- Each batch is HPLC-verified at ≥98% purity, with mass spectrometry confirming identity. COA included with every shipment.
- Store the lyophilised compound at -20 °C, protected from light and moisture. Once dissolved, follow standard small-molecule handling — most NNMT inhibitor research uses fresh stock solutions for optimal reproducibility.
- 5-Amino-1MQ is studied in adipocyte cultures, metabolic disease models, and obesity research. NNMT is implicated in energy expenditure regulation, and NNMT inhibitors are an active research area in metabolic biology.
- No. 5-Amino-1MQ is an experimental research compound and has no approved therapeutic use. Supplied by Peptra Labs for laboratory research only.