NAD+
An essential coenzyme present in all living cells, participating in over 500 enzymatic reactions, studied for cellular energy metabolism, DNA repair, sirtuin activation, and age-related decline. All presented information is based on scientific publications which can be found at the end of product description below.
Product Specifications
Descriere
Toate informațiile prezentate se bazează pe publicații științifice, care pot fi consultate la sfârșitul descrierii produsului, mai jos.
NAD+ (nicotinamide adenine dinucleotide) is a fundamental coenzyme functioning as a critical electron carrier and substrate for DNA repair, gene expression regulation, and cellular signaling enzymes.
Research Highlights
1. Energy Metabolism — Essential cofactor in glycolysis, citric acid cycle, and oxidative phosphorylation.
2. Sirtuin Activation — Obligate substrate for SIRT1-7, controlling deacetylation of histones and proteins.
3. DNA Repair — PARP enzymes consume NAD+ for poly-ADP-ribosylation during damage repair.
4. Age-Related Decline — Progressive depletion across tissues correlates with metabolic dysfunction and inflammation.
5. Neuroprotection — Supplementation may protect against neurodegeneration through enhanced mitochondrial function.
References available upon request.
The product is intended for scientific research and development purposes only. Chemical substances shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals. Intended only for in-vitro research, such as Receptor-ligand binding studies, Enzyme activity assays, Cell proliferation assays, Cell signaling assays, Epitope mapping, etc.
Doar pentru uz de cercetare: Produsul este destinat exclusiv scopurilor de cercetare științifică și dezvoltare. Substanțele chimice nu trebuie utilizate ca medicament, substanță activă, ajutor medical, produs cosmetic, substanță pentru producerea unui produs cosmetic și nici pentru consum uman ca aliment sau supliment alimentar și nici utilizate în alt mod similar pe oameni sau animale. Destinat exclusiv pentru cercetare in-vitro, precum studii de legare receptor-ligand, teste de activitate enzimatică, teste de proliferare celulară, teste de semnalizare celulară, mapare a epitopilor etc.
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Întrebări frecvente
- NAD+ (nicotinamide adenine dinucleotide) is technically a coenzyme (a pyridine nucleotide), not a peptide — molecular formula C₂₁H₂₇N₇O₁₄P₂, MW ≈ 663.43 g/mol. It is included in the Peptra Labs research catalog because of its central role in metabolism, sirtuin activity, and aging research.
- Each batch is HPLC-verified at ≥99% purity, with attention to the oxidized (NAD+) vs reduced (NADH) state. The COA confirms identity and form.
- Store lyophilised NAD+ at -20 °C, sealed and protected from light and moisture. NAD+ is hygroscopic and degrades to ADP-ribose under aqueous conditions, especially at neutral or alkaline pH. Reconstitute in slightly acidic buffer for best stability and use promptly.
- NAD+ is used in research on cellular bioenergetics, sirtuin enzyme activity (SIRT1-7), poly-ADP-ribose polymerase (PARP) pathways, redox biology, and aging models. NAD+ levels decline with age in many tissues, motivating extensive aging-research interest.
- NAD+ is sold as a dietary supplement in some markets but is not an FDA-approved drug for any specific indication. Research-grade NAD+ from Peptra Labs is for laboratory research only.
